Tango Therapeutics Bolsters Expertise in Oncology Translational Research and Clinical Pharmacology with Leadership Expansion

CAMBRIDGE, Mass. May 9, 2018– Tango Therapeutics today announced an expansion of its management team with the promotion of Alan Huang, Ph.D., to chief scientific officer and the addition of Charles Davis, Ph.D., as senior vice president, pharmaceutical sciences (DMPK, safety assessment and clinical pharmacology).

The new appointments bolster Tango’s expertise in oncology translational research and clinical pharmacology as the company advances its goal of creating novel, targeted medicines for specific cancer subtypes using the principle of synthetic lethality.

“We are thrilled to have Alan leading our scientific efforts. His wealth of experience in oncology research and his strategic approach to building Tango’s target and drug discovery platform will help us in our drive to get important new drugs to the patients who need them most,” said Barbara Weber, M.D., Tango’s chief executive officer. “I’m also delighted to welcome Charles to lead our pharmaceutical sciences capabilities. His expertise will be vital as we build a fully integrated biopharma company with capabilities from target discovery through clinical development and commercialization.”

Alan Huang, Ph.D., joined Tango Therapeutics as senior vice president, head of biology, after serving as a consultant at Third Rock Ventures, where he played a leading role in the creation and launch of Tango. At Tango, Alan has led the process of designing and building Tango’s novel, CRISPR-based, target discovery platform, and has been instrumental in advancing programs in drug discovery. Before joining Third Rock, Alan worked at the Novartis Institutes for BioMedical Research as senior director and interim global head of oncology translational research. Under his leadership, the group advanced multiple Novartis compounds through development. He began his career at Millennium Pharmaceuticals. Alan earned his B.S. in biochemistry from Fudan University and his doctorate in biochemistry and molecular biology from the University of South Alabama. He is an author on more than 30 peer-reviewed publications and holds nearly 20 patents.

“I’m excited to be expanding my role at Tango at a time when we’ve validated our approach and we’re moving ahead with a clear sense of purpose to produce therapeutic breakthroughs for patients,” Alan said.

Charles Davis, Ph.D., comes to Tango from the Novartis Institutes for BioMedical Research, where he served as vice president, PK sciences. At NIBR, he led an international team of scientists representing the PKS discipline on more than 100 projects and was a member of the PKS Leadership Team, the Integrated Cancer Board and the Oncology Development Leadership Team. Before joining Novartis, Charles spent more than 20 years at GlaxoSmithKline, where he served on the leadership teams of three of GSK's Centers of Excellence in Drug Discovery. Charles has a B.A. in chemistry from Swarthmore College and a Ph.D. in biophysical chemistry from Cornell University.

“Tango’s science is truly exciting,” Charles said. “This is a dynamic team and I’m glad to come aboard as we work together to build on our strong scientific foundation to advance multiple programs to the clinic.”

About Tango Therapeutics

Tango Therapeutics, a 2017 “Fierce 15” company, is a biotechnology company developing novel therapies targeting context-dependent vulnerabilities in cancers. Tango’s robust product engine is designed to support the discovery and development of breakthrough medicines that provide deeper, more sustained benefit than today’s targeted therapies, and that extend the benefits of available immuno-oncology agents. The company’s programs are focused in the area of synthetic lethality, the interaction between two genes that causes cell death when both are inactivated. Tango was launched in 2017 with a $55 million Series A investment funded by Third Rock Ventures. For more information, please visit www.tangotx.com.

Media Contact:
Stephanie Simon, Ten Bridge Communications
stephanie@tenbridgecommunications.com
617-581-9333

Tango Therapeutics Expands Board of Directors with the Addition of Leading Oncology Experts with Deep Experience in Targeted and Personalized Therapies

CAMBRIDGE, Mass. March 8, 2018 – Tango Therapeutics, a biotechnology company creating novel, targeted medicines for specific cancer subtypes, today announced the addition of three experienced leaders with deep backgrounds in personalized cancer research, drug discovery and development to the board of directors.

Joining the board are Michael Pellini, M.D., MBA, chairman of Foundation Medicine and managing partner at Section 32; Allen Oliff, M.D., an oncologist and senior vice president in research and development at GlaxoSmithKline; and Pablo Cagnoni, M.D., the president and chief executive officer of Tizona Therapeutics. All are leading experts in oncology R&D.

“We are proud to bring in three leaders with extensive experience in cancer research and development and an unwavering commitment to bringing transformative, targeted medicines to patients,” said Barbara Weber, M.D., Tango’s chief executive officer. “Their expertise, insights and commitment to this field will help Tango immensely as we create a new generation of breakthrough cancer therapies.”

Michael Pellini, M.D., MBA, joined Foundation Medicine as president and chief executive in 2011 and transitioned to chairman last year. In addition to his role at Foundation Medicine, Dr. Pellini is managing partner of Section 32, a California-based technology and life sciences venture fund (Section 32 is not a Tango investor). Dr. Pellini joined Foundation Medicine from Clarient, Inc., which was acquired by GE Healthcare in 2010, where he was president, chief operating officer and served on its board of directors. A physician with over 20 years of experience at the forefront of the clinical diagnostics and laboratory industries, Dr. Pellini brings a depth of understanding of personalized medicine, with a particular interest and focus in oncology. He serves as a member of the board of directors for the Personalized Medicine Coalition and the Mission Hospital Foundation (Provident/St. Joseph Health), as well as several biotechnology companies. He is also a member of the President’s Leadership Council for the Sydney Kimmel Medical College at Thomas Jefferson University and the Advisory Board for Mission Hospital’s Cancer Institute.

Allen Oliff, M.D., brings over three decades of experience in oncology R&D to the Tango Board of Directors. He has held numerous leadership positions at GSK and has led the development of seven marketed products and two other agents in late-stage development, including the portfolio of oncology drugs acquired by Novartis in 2015. Before joining GSK, Dr. Oliff held leadership positions at DuPont Pharmaceuticals and Merck and Co., where he was executive director of cancer research. Earlier in his career, as an oncology researcher, he authored more than 120 peer-reviewed publications on the molecular pathogenesis of cancer, with a focus on RNA tumor viruses, oncogenes and tumor suppressor genes.

Pablo Cagnoni, M.D., brings three decades of experience in developing and commercializing life-changing medicines for cancer patients. He has played a key role in bringing numerous oncology drugs to market, including Tarceva, Afinitor, Kyprolis and Zykadia, among many others. Dr. Cagnoni currently serves as president and CEO of Tizona Therapeutics. He previously served as president of Onyx Pharmaceuticals, where he had global strategic oversight of the business from early product development through commercialization. Prior to moving to Onyx, Dr. Cagnoni served as senior vice president and global head of clinical development at Novartis Oncology, where he was responsible for all late-stage clinical development for the oncology pipeline.

About Tango Therapeutics

Tango Therapeutics, a 2017 “Fierce 15” company, is a biotechnology company developing novel therapies targeting context-dependent vulnerabilities in cancers. Tango’s robust product engine is designed to support the discovery and development of breakthrough medicines that provide deeper, more sustained benefit than today’s targeted therapies, and that extend the benefits of available immuno-oncology agents. The company’s programs are focused in the area of synthetic lethality, the interaction between two genes that causes cell death when both are inactivated. Tango was launched in 2017 with a $55 million Series A investment funded by Third Rock Ventures. For more information, please visit www.tangotx.com.

Media Contact:
Stephanie Simon, Ten Bridge Communications
stephanie@tenbridgecommunications.com
617-581-9333

Tango Therapeutics Announces the Addition of Shakti Narayan, Ph.D., J.D. as Chief Business Officer

CAMBRIDGE, Mass., December 6, 2017 – Tango Therapeutics, a biotechnology company creating novel, targeted medicines for specific cancer subtypes, today announced that Shakti Narayan, Ph.D., J.D., has joined the company as Tango’s Chief Business Officer.

Narayan brings extensive leadership experience in business development, operations and legal operations within the biotechnology and pharmaceuticals industries, most recently through his role as Vice President and Head of Transactions at Johnson & Johnson (J&J) Innovation in Boston. At J&J, he helped build the company’s Innovation Centers model, where he led oncology business development efforts and led a team that drove strategic transactions spanning multiple J&J businesses. His full biography is available here.

In addition, Tango announced today that Dimitris Papoutsakis, Ph.D., has joined the company as Vice President of Operations, Program and Portfolio Management. Dimitris joins Tango from Novartis Oncology, where he worked most recently in oncology business development and licensing roles. In addition, Tania Philipp has joined the company as Vice President of Human Resources from global human resources at Bavarian Nordic.

“We are thrilled to add these talented and committed individuals to our senior leadership team as we build a world-class drug discovery and development organization that is leading the way in creating new synthetic lethal approaches for cancer,” said Barbara Weber, M.D., Tango’s Chief Executive Officer. “Shakti’s track record in establishing strong partnerships to advance promising early discoveries will support an important pillar of our strategy as we develop the broad potential of our platform through both our own internal efforts, and through activities we undertake with partners.”

About Tango Therapeutics

Tango Therapeutics, a 2017 “Fierce 15” company, is a biotechnology company developing novel therapies targeting context-dependent vulnerabilities in cancers. Tango’s robust product engine is designed to support the discovery and development of breakthrough medicines that provide deeper, more sustained benefit than today’s targeted therapies, and that extend the benefits of available immuno-oncology agents. The company’s programs are focused in the area of synthetic lethality, the interaction between two genes that causes cell death when both are inactivated. Tango was launched in 2017 with a $55 million Series A investment funded by Third Rock Ventures. For more information, please visit www.tangotx.com.

Media Contact:
Dan Quinn, Ten Bridge Communications
dan@tenbridgecommunications.com
781-475-7974

Tango Therapeutics Appoints Barbara Weber, MD, as Chief Executive Officer

CAMBRIDGE, Mass., September 25, 2017 – Tango Therapeutics, a biotechnology company creating novel, context-dependent medicines for cancer, today announced that Barbara Weber, M.D., has been named the company’s full-time Chief Executive Officer. Dr. Weber will transition from her current role as interim Chief Executive Officer of Tango, and will continue as a Venture Partner at Third Rock Ventures.

Third Rock Ventures Launches Tango Therapeutics with $55 Million Series A Investment

Company targeting context-dependent vulnerabilities in cancers for patients without effective treatment options

CAMBRIDGE, Mass., March 30, 2017 – Third Rock Ventures, LLC today announced the launch of Tango Therapeutics, a new cancer therapeutics company discovering and developing novel medicines designed to target cancer vulnerabilities beyond mutated oncogenes to deliver transformational new therapies for patients.