John G. Doench, PhD

John G. Doench, PhDDirector R&D, Institute Scientist, at Broad Institute of MIT and Harvard

John G. Doench is an Institute Scientist at the Broad Institute of MIT and Harvard. In that capacity, he provides expert guidance on the design, execution, and analysis of genetic screens. He has contributed to numerous publications in fields such as infectious disease, cancer biology, and immunology, highlighting both his commitment to team-based science and ability to mentor and guide scientists from diverse backgrounds on the critical principles of genetic screens.

Additionally, as the Director of R&D in the Genetic Perturbation Platform (GPP), John leads a group focused on the development of functional genomic techniques, first with RNAi and more recently with CRISPR technology. Here, his team demonstrated the potential of genetic screens with CRISPR and has since developed leading bioinformatics tools and screening libraries to enable community-wide usage of this powerful technology.

Prior to joining the Broad in 2009, John did his postdoctoral work at Harvard Medical School, received his PhD from the biology department in Phil Sharp’s lab at MIT, and majored in history at Hamilton College.